PhanerochaeteV1, Main, Exploration, bibRecord, 000019

Natural trypanocidal product produced by endophytic fungi through co-culturing.

Identifieur interne : 000019 ( Main/Exploration ); précédent : 000018; suivant : 000020

Natural trypanocidal product produced by endophytic fungi through co-culturing.

Auteurs : Jainara Santos Do Nascimento [Brésil] ; Felipe Moura Silva [Brésil] ; Cynthia Alejandra Magallanes-Noguera [Argentine] ; Marcela Kurina-Sanz [Argentine] ; Elda Gonçalves Dos Santos [Brésil] ; Ivo Santana Caldas [Brésil] ; Jaine Honorata Hortolan Luiz [Brésil] ; Eliane De Oliveira Silva [Brésil]

Source :

Folia microbiologica [ 1874-9356 ] ; 2020.

RBID : pubmed:31250361

Descripteurs français

KwdFr :
- Endophytes (composition chimique), Endophytes (croissance et développement), Endophytes (génétique), Feuilles de plante (microbiologie), Phanerochaete (composition chimique), Phanerochaete (croissance et développement), Phanerochaete (génétique), Phanerochaete (métabolisme), Tabebuia (microbiologie), Talaromyces (composition chimique), Talaromyces (croissance et développement), Talaromyces (génétique), Talaromyces (métabolisme), Techniques de coculture (MeSH), Terpènes (analyse), Terpènes (métabolisme), Terpènes (pharmacologie), Trypanocides (analyse), Trypanocides (métabolisme), Trypanocides (pharmacologie), Trypanosoma cruzi (croissance et développement), Trypanosoma cruzi (effets des médicaments et des substances chimiques).
MESH :
- analyse : Terpènes, Trypanocides.
- composition chimique : Endophytes, Phanerochaete, Talaromyces.
- croissance et développement : Endophytes, Phanerochaete, Talaromyces, Trypanosoma cruzi.
- effets des médicaments et des substances chimiques : Trypanosoma cruzi.
- génétique : Endophytes, Phanerochaete, Talaromyces.
- microbiologie : Feuilles de plante, Tabebuia.
- métabolisme : Phanerochaete, Talaromyces, Terpènes, Trypanocides.
- pharmacologie : Terpènes, Trypanocides.
- Techniques de coculture.

English descriptors

KwdEn :
- Coculture Techniques (MeSH), Endophytes (chemistry), Endophytes (genetics), Endophytes (growth & development), Phanerochaete (chemistry), Phanerochaete (genetics), Phanerochaete (growth & development), Phanerochaete (metabolism), Plant Leaves (microbiology), Tabebuia (microbiology), Talaromyces (chemistry), Talaromyces (genetics), Talaromyces (growth & development), Talaromyces (metabolism), Terpenes (analysis), Terpenes (metabolism), Terpenes (pharmacology), Trypanocidal Agents (analysis), Trypanocidal Agents (metabolism), Trypanocidal Agents (pharmacology), Trypanosoma cruzi (drug effects), Trypanosoma cruzi (growth & development).
MESH :
- chemical , analysis : Terpenes, Trypanocidal Agents.
- chemistry : Endophytes, Phanerochaete, Talaromyces.
- drug effects : Trypanosoma cruzi.
- genetics : Endophytes, Phanerochaete, Talaromyces.
- growth & development : Endophytes, Phanerochaete, Talaromyces, Trypanosoma cruzi.
- metabolism : Phanerochaete, Talaromyces, Terpenes, Trypanocidal Agents.
- microbiology : Plant Leaves, Tabebuia.
- chemical , pharmacology : Terpenes, Trypanocidal Agents.
- Coculture Techniques.

Abstract

Endophytic fungi live inside vegetal tissues without causing damage to the host plant and may provide lead compounds for drug discovery. The co-culture of two or more endophytic fungi can trigger silent gene clusters, which could lead to the isolation of bioactive compounds. In this study, two endophytic strains isolated from Handroanthus impetiginosus leaves, identified as Talaromyces purpurogenus H4 and Phanerochaete sp. H2, were grown in mixed and axenic cultures. The meroterpenoid austin was detected only in the extracts from the mixed culture. Once isolated, austin displayed very interesting trypanocidal activity, with an IC₅₀ value of 36.6 ± 1.2 μg/mL against Trypanosoma cruzi in the epimastigote form. The results obtained highlight the importance of the co-culturing of endophytic fungi to obtain natural bioactive products. The findings also enhance our understanding of the ecological relationships between endophytic fungi.

DOI: 10.1007/s12223-019-00727-x
PubMed: 31250361

Affiliations:

Argentine, Brésil

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000060
to stream Main, to step Curation: 000060

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coculture Techniques (MeSH)</term>
<term>Endophytes (chemistry)</term>
<term>Endophytes (genetics)</term>
<term>Endophytes (growth & development)</term>
<term>Phanerochaete (chemistry)</term>
<term>Phanerochaete (genetics)</term>
<term>Phanerochaete (growth & development)</term>
<term>Phanerochaete (metabolism)</term>
<term>Plant Leaves (microbiology)</term>
<term>Tabebuia (microbiology)</term>
<term>Talaromyces (chemistry)</term>
<term>Talaromyces (genetics)</term>
<term>Talaromyces (growth & development)</term>
<term>Talaromyces (metabolism)</term>
<term>Terpenes (analysis)</term>
<term>Terpenes (metabolism)</term>
<term>Terpenes (pharmacology)</term>
<term>Trypanocidal Agents (analysis)</term>
<term>Trypanocidal Agents (metabolism)</term>
<term>Trypanocidal Agents (pharmacology)</term>
<term>Trypanosoma cruzi (drug effects)</term>
<term>Trypanosoma cruzi (growth & development)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Endophytes (composition chimique)</term>
<term>Endophytes (croissance et développement)</term>
<term>Endophytes (génétique)</term>
<term>Feuilles de plante (microbiologie)</term>
<term>Phanerochaete (composition chimique)</term>
<term>Phanerochaete (croissance et développement)</term>
<term>Phanerochaete (génétique)</term>
<term>Phanerochaete (métabolisme)</term>
<term>Tabebuia (microbiologie)</term>
<term>Talaromyces (composition chimique)</term>
<term>Talaromyces (croissance et développement)</term>
<term>Talaromyces (génétique)</term>
<term>Talaromyces (métabolisme)</term>
<term>Techniques de coculture (MeSH)</term>
<term>Terpènes (analyse)</term>
<term>Terpènes (métabolisme)</term>
<term>Terpènes (pharmacologie)</term>
<term>Trypanocides (analyse)</term>
<term>Trypanocides (métabolisme)</term>
<term>Trypanocides (pharmacologie)</term>
<term>Trypanosoma cruzi (croissance et développement)</term>
<term>Trypanosoma cruzi (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Terpenes</term>
<term>Trypanocidal Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Terpènes</term>
<term>Trypanocides</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Endophytes</term>
<term>Phanerochaete</term>
<term>Talaromyces</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Endophytes</term>
<term>Phanerochaete</term>
<term>Talaromyces</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Endophytes</term>
<term>Phanerochaete</term>
<term>Talaromyces</term>
<term>Trypanosoma cruzi</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Trypanosoma cruzi</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Trypanosoma cruzi</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Endophytes</term>
<term>Phanerochaete</term>
<term>Talaromyces</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Endophytes</term>
<term>Phanerochaete</term>
<term>Talaromyces</term>
<term>Trypanosoma cruzi</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Endophytes</term>
<term>Phanerochaete</term>
<term>Talaromyces</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phanerochaete</term>
<term>Talaromyces</term>
<term>Terpenes</term>
<term>Trypanocidal Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Feuilles de plante</term>
<term>Tabebuia</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Leaves</term>
<term>Tabebuia</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Phanerochaete</term>
<term>Talaromyces</term>
<term>Terpènes</term>
<term>Trypanocides</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Terpènes</term>
<term>Trypanocides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Terpenes</term>
<term>Trypanocidal Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Coculture Techniques</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Techniques de coculture</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Endophytic fungi live inside vegetal tissues without causing damage to the host plant and may provide lead compounds for drug discovery. The co-culture of two or more endophytic fungi can trigger silent gene clusters, which could lead to the isolation of bioactive compounds. In this study, two endophytic strains isolated from Handroanthus impetiginosus leaves, identified as Talaromyces purpurogenus H4 and Phanerochaete sp. H2, were grown in mixed and axenic cultures. The meroterpenoid austin was detected only in the extracts from the mixed culture. Once isolated, austin displayed very interesting trypanocidal activity, with an IC<sub>50</sub>
 value of 36.6 ± 1.2 μg/mL against Trypanosoma cruzi in the epimastigote form. The results obtained highlight the importance of the co-culturing of endophytic fungi to obtain natural bioactive products. The findings also enhance our understanding of the ecological relationships between endophytic fungi.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>30</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>65</Volume>
<Issue>2</Issue>
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<Month>Apr</Month>
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<Title>Folia microbiologica</Title>
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</Journal>
<ArticleTitle>Natural trypanocidal product produced by endophytic fungi through co-culturing.</ArticleTitle>
<Pagination><MedlinePgn>323-328</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s12223-019-00727-x</ELocationID>
<Abstract><AbstractText>Endophytic fungi live inside vegetal tissues without causing damage to the host plant and may provide lead compounds for drug discovery. The co-culture of two or more endophytic fungi can trigger silent gene clusters, which could lead to the isolation of bioactive compounds. In this study, two endophytic strains isolated from Handroanthus impetiginosus leaves, identified as Talaromyces purpurogenus H4 and Phanerochaete sp. H2, were grown in mixed and axenic cultures. The meroterpenoid austin was detected only in the extracts from the mixed culture. Once isolated, austin displayed very interesting trypanocidal activity, with an IC<sub>50</sub>
 value of 36.6 ± 1.2 μg/mL against Trypanosoma cruzi in the epimastigote form. The results obtained highlight the importance of the co-culturing of endophytic fungi to obtain natural bioactive products. The findings also enhance our understanding of the ecological relationships between endophytic fungi.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>do Nascimento</LastName>
<ForeName>Jainara Santos</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Organic Chemistry Department, Chemistry Institute, Federal University of Bahia, Barão de Jeremoabo, Salvador, Bahia, 40170-115, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Silva</LastName>
<ForeName>Felipe Moura</ForeName>
<Initials>FM</Initials>
<AffiliationInfo><Affiliation>Organic Chemistry Department, Chemistry Institute, Federal University of Bahia, Barão de Jeremoabo, Salvador, Bahia, 40170-115, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Magallanes-Noguera</LastName>
<ForeName>Cynthia Alejandra</ForeName>
<Initials>CA</Initials>
<AffiliationInfo><Affiliation>INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kurina-Sanz</LastName>
<ForeName>Marcela</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.</Affiliation>
</AffiliationInfo>
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	Serveur d'exploration sur le phanerochaete
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Natural trypanocidal product produced by endophytic fungi through co-culturing.

Natural trypanocidal product produced by endophytic fungi through co-culturing.

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